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Regular Price: $89.98 Sale Price: $69.95 Limited Offer!!! FREE SHIPPING NO TAXES » Home » About » Niteworks » Dr Louis Ignarro » Nitric Oxide » FAQ » L-Arginine » L-Citrulline » Amino Acids » Product Label » Disclaimer » Niteworks Trial Size » Links |
L-Citrulline / CitrullineL-Citrulline / Citrulline is an amino acid that supports the body in optimizing blood flow through its conversion to L-arginine and then nitric oxide. Nitric oxide is involved in vasodilatation, and low levels are associated with mental and physical fatigue and sexual dysfunction.Citrulline, which is considered a non-essential amino acid synthesized in the intestinal tract from Glutamine, converts to Arginine in the endothelial cells. This biochemical process involves L-Aspartate and the enzymes Argininosuccinate Synthetase and Argininosuccinate Lyase, in the presence of ATP. Arginine is important for Nitric Oxide production for cardiovascular health; however, most Arginine is utilized in the liver and kidneys, and only a fraction is available for this purpose. Since Citrulline is a precursor to Arginine, it allows for increased and sustained Nitric Oxide production in the endothelium for support of circulatory function. Oral Citrulline supplementation provides a readily available source of Citrulline for this purpose, and some recent research further indicates that Citrulline may be the preferred source of cellular Arginine. In addition Citrulline also increases energy, stimulates the immune system, and is essential for Urea Cycle function as well. how L-citrulline and L-taurine fit into the Niteworks® formulaA: L-citrulline is of critical importance because of its synergistic role with L-arginine in the production of Nitric Oxide, or NO. L-citrulline is actually a by-product in the production of NO and is recycled by the body to make more L-arginine to form NO. This “recycling” action is further enhanced because L-citrulline and L-arginine reach cells by different paths, resulting in broader support for NO production. L-taurine has been shown to strengthen the heart muscle, and as an antioxidant, it protects NO during its brief lifetime.*Watermelon has citrullineWatermelon consumption increases plasma arginine concentrations in adults. Nutrition. 2007 March. Collins JK, Wu G, Perkins-Veazie P, Spears K, Claypool PL, Baker RA, Clevidence BA. USDA-ARS, South Central Agricultural Research Laboratory, Lane, Oklahoma, USA.
Watermelon is a rich source of citrulline. No detailed studies have been conducted to evaluate plasma arginine response in humans after long-term feeding of citrulline from natural plant sources. This study investigated if watermelon juice consumption increases fasting concentrations of plasma arginine, ornithine, and citrulline in healthy adult humans. Subjects consumed a controlled diet and 0 (control), 780, or 1560 g of watermelon juice per day for 3 weeks in a crossover design. The treatments provided 1 and 2 g of citrulline per day. Compared with the baseline, fasting plasma arginine concentrations increased 12% after 3 wk of the lower-dose watermelon treatment; arginine and ornithine concentrations increased 22% and 18%, respectively, after 3 wk of the higher-dose watermelon treatment. Fasting citrulline concentrations did not increase relative to the control but remained stable throughout the study. The increased fasting plasma concentrations of arginine and ornithine and stable concentrations of plasma citrulline in response to watermelon juice consumption indicated that the citrulline from this plant origin was effectively converted into arginine.
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