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What is Nitric Oxide?

With heart health a leading concern among both men and women in America, you need every advantage you can get in protecting yourself. The discovery of an amazing molecule, nitric oxide (NO), can help provide you with just this sort of protection.

NO improves circulation by helping blood vessels signal the surrounding smooth muscle to relax–which widens the arteries, increases blood flow and helps maintain normal blood pressure. NO keeps your system youthful, toned, and flexible. In fact, optimizing NO production is like giving your cardiovascular system a workout every day! In addition to its numerous heart-health benefits, NO also promotes immune-system health and acts as a neurotransmitter.

Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. In humans, a high-salt intake was demonstrated to attenuate NO production.

Nitric oxide is also generated by macrophages and neutrophils as part of the human immune response. Nitric oxide is toxic to bacteria and other human pathogens. In response, however, many bacterial pathogens have evolved mechanisms for nitric oxide resistance. Because nitric oxide might serve as an inflammometer in conditions like asthma, there has been increasing interest in the use of exhaled nitric oxide as a breath test in diseases with airway inflammation.

If Nitric Oxide is a gas, why does Niteworks® come in powder form?

Herbalife developed Niteworks® with Dr. Lou Ignarro, who won the Nobel Prize in Medicine. Dr. Ignarro’s research showed that Nitric Oxide helps to keep blood vessels toned, flexible and youthful for improved circulation.* His research further showed that Nitric Oxide enhances blood flow, supporting function of the heart, brain and other organs.* His additional research has shown that the combination of two amino acids, L-Arginine and L-Citrulline, helps to support Nitric Oxide production in the body. Herbalife developed Niteworks® as a powder with these two amino acids. This product also contains Alpha Lipoic Acid and Vitamin E for antioxidant protection.*

How much should be taken? Are there any side effects?

With any amino acid containing product, overdose is a possibility. Dosing with too much arginine can lead to diarrhea, weakness and nausea. Clear dosing guidelines have not been established, so it is best to do what is known as "tolerance mapping". Take a small dosage for one week, note the benefits and the side effects, and increase the dosage until the benefits are maximized and the side effects minimized. Over time the two will converge and you will hit the optimal dose. This process is similar to "receptor mapping" for bodybuilders who use insulin. Many protein powders are fortified with amino acids, including arginine. With this in mind, pay particular attention to how much arginine you are ingesting from all supplements taken.

More Nitric Oxide information

NO is one of the few gaseous signaling molecules known. It is a key vertebrate biological messenger, playing a role in a variety of biological processes. Nitric oxide, known as the 'endothelium-derived relaxing factor', or 'EDRF', is biosynthesised endogenously from arginine and oxygen by various nitric oxide synthase (NOS) enzymes and by reduction of inorganic nitrate. The endothelium (inner lining) of blood vessels use nitric oxide to signal the surrounding smooth muscle to relax, thus resulting in vasodilation and increasing blood flow. Nitric oxide is highly reactive (having a lifetime of a few seconds), yet diffuses freely across membranes. These attributes make nitric oxide ideal for a transient signal molecule between adjacent cells and within cells. The production of nitric oxide is elevated in populations living at high-altitudes, which helps these people avoid hypoxia. Effects include blood vessel dilatation, neurotransmission (see Gasotransmitters), modulation of the hair cycle, and penile erections. Nitroglycerin and amyl nitrite serve as vasodilators because they are converted to nitric oxide in the body. Sildenafil, popularly known by the trade name Viagra, stimulates erections primarily by enhancing signaling through the nitric oxide pathway in the penis.